Clomipramine and the enzymes CYP2D6 and CYP2C19
Clomipramine is processed to a large extent by the enzymes CYP2D6 and CYP2C19.
Initially, clomipramine is metabolised (demethylated) by the enzyme CYP2C19 into another active substance. The enzymes CYP1A2 and CYP3A4 are also involved in this step to a lesser extent. After this activation step this substance is metabolised further (hydroxylated) by the enzyme CYP2D6 into less active components.
The activity of the enzymes concerned can vary considerably depending on your genetic predisposition, which means the efficacy of clomipramine can also differ from person to person. Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with clomipramine.
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