Recent research proves: fewer side effects thanks to a DNA test
A recent study, published in The Lancet, proves conclusively that tailored medication, based on DNA, leads to fewer side effects.
In this study, 50 variants in 12 genes were mapped. These genes* contain the code for making certain enzymes and transport proteins. These are important in the processing of medicines. Certain genetic variations lead to increased or reduced activity of an enzyme. This affects the dose or choice of a medicine. Guidelines for dosage advice have been drawn up by the DPWG (Dutch Pharmacogenetics Working Group).
*CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A5, DPYD, F5, HLA-B, SLCO1B1, TPMT, UGT1A1, VKORC1
6,944 people from seven different countries took part in the study. One half was treated as usual and the other half had a DNA test before the treatment.
The study shows that a DNA test before medicine treatment is very effective in preventing side effects. In the first group, 28.6% of people experienced clinically relevant side effects. In the group with a DNA passport this was only 21.5%. That is an impressive reduction of 30%.
An interesting detail is that 93.5% of the participants had one or more variants that, when a certain medicine was prescribed, would lead to a dosage advice. Deviations in medicine use are therefore more the rule than the exception.
iGene Pharma package
Since 2019, iGene has offered a pharmacogenetic passport. In addition to the 12 genes from the above-mentioned study, it also maps a number of other enzymes.
With the DNA test iGene FARMA it is possible to identify preventively which medicines you probably respond to differently. In your personal pharmacogenetic profile you can also see which enzymes play a role in this.
In short: a comprehensive pharmacogenetic passport. With it, a doctor or pharmacist can immediately choose the right medicine and the right dose for you, based on the latest pharmacogenetic knowledge.
The NOS news report of 3 February 2023 about the study published in The Lancet on tailored medication.
What is ‘pharmacogenetics’?
Pharmacogenetics is the field in which research is carried out into the influence of genetic variations in relation to an individual’s response to a medicine. Genetic variations, which occur naturally, can mean that medicines are processed more slowly or more quickly than average. This affects not only the effectiveness of the medication, but can also influence the extent and severity of side effects.