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As complex as DNA technology is, the iGenius DNA dashboard is just as simple to use. Your client provides a little saliva, and as soon as the results have been processed, you see them clearly arranged in the dashboard: by section, with points of attention and advice.
The quickest way to get to know the iGenius dashboard.
Watch this 3-minute demo. Then you’ll see straight away how to go through your client’s results, and how to get from insight to advice. Below you can read everything the dashboard contains.
Demo of the iGenius DNA dashboard3 minutes · De video speelt via YouTube.
Made for treatment practice
Genetic insight, translated into your treatment.
Results and advice are based on more than 10,000 validated studies. The pharmacogenetics follows the guidelines of the KNMP and DPWG, and our scientific team continuously updates the database.
Colour codesEvery result has a colour. That way you see immediately which genes are normal and which need attention.
Clickable diagramsExplore genetic pathways with diagrams that show the link between genes, biochemical processes and symptoms.
Supporting evidence for every insightClick on a result for the explanation, clinical considerations and the scientific studies behind it.
From insight to adviceConsiderations for diagnostics, treatment and lifestyle, such as nutrition, supplements or stress reduction.
You choose what your client seesShare only what is relevant, in the app or as a PDF report, add a note, and put sensitive results behind a reflection lock.
Support with questionsOur genetics experts help you by email and phone.
What’s in the dashboard?
Two layers: your client’s predisposition, and the bioprocesses.
Your client’s predispositionPersonal traits, conditions and medicinesYour client sees this part in the iGene app too. You look along, so that you can include it in your treatment.
Personal traits influence nutrition, health and physical characteristics. Think of food intolerances (gluten, fructose, lactose), metabolic and blood clotting disorders and physical traits. For each trait you see which variants contribute, with concrete pointers.
For each condition you see whether your client has an increased or reduced genetic risk, with the relevant gene variants, a scientific explanation and practical lifestyle advice. To be used in treatment plans, lifestyle guidance or preventive care advice.
More than 95% of people have one or more variants for which adjusted dosage advice applies. For each enzyme, transport protein or HLA type you see what this means for breakdown, activation, absorption or sensitivity, based on the guidelines of the KNMP/DPWG. For more extensive pharmacogenetics there is iGene Pharmaco with the PGx Dose Support system.
Insight into a number of common conditions that can play a role in fertility, pregnancy and pregnancy loss, with the underlying processes for each condition.
BioprocessesThe 7 processes that keep the body runningThe core of your analysis: how processes such as methylation, detoxification and inflammation work in your client, with the enzymes involved and the diagrams from the dashboard.
Process 1 of 7
Methylation
Methylation, or ‘one-carbon metabolism’, is an essential process that takes place in all cells of the body. Various enzymes are involved, including MTHFR, MTR, MTRR, BHMT and CBS. Methylation is important in many different processes, such as the production of energy, gene expression (epigenetics), detoxification, the formation and breakdown of hormones and neurotransmitters, and the building and repair of tissues and cells.
Genetic variants can influence the effectiveness of the methylation enzymes involved. Because methylation plays a role in many crucial processes, less than optimal methylation can lead to various physical symptoms.
Routes and enzymes involved
Folate pathway: conversion to methionine via MTR, MTRR and MTHFR (with MTHFD)
Betaine pathway: conversion to methionine via BHMT
Transsulfuration pathway: conversion to cysteine via CBS, with further conversion to taurine or glutathione
Methyltransferases such as COMT, HNMT and BHMT
Genetic factors
Genetic variations and mutations can influence the functionality of proteins, such as enzymes and receptors, directly or indirectly. This can happen through an individual genetic change in a single gene, but also through interaction with other genetic or environmental factors. A thorough analysis of these variations and how they relate to each other can provide valuable insights.
In addition to genetic predisposition, lifestyle and environmental factors also influence methylation. Essential co-factors for a well-functioning methylation process are vitamin B2, B6, B9 (folate), B12, serine, methionine, betaine (TMG), choline and SAM. Genetic variations are therefore rarely the only cause of disrupted methylation, but they can point to an increased risk of reduced methylation capacity.
Clinical relevance and other factors
An inefficient methylation process is associated with various conditions and symptoms:
cardiovascular disease
mood disorders (depression, anxiety)
cancer
tiredness
premature ageing
neural tube defects and Down’s syndrome
unexplained miscarriages
infertility (in men too)
Alzheimer’s and dementia
insulin resistance and diabetes
autoimmune diseases
ADHD
The process illustrated
In the dashboard you see this diagram with your client’s result in it: for each step whether an enzyme works normally, more slowly or more quickly, and which cofactors play a role.
Methylation: folate cycle, methionine cycle and transsulfuration pathway, with the B vitamins that act as co-factors.
Process 2 of 7
Detoxification
The body is continuously exposed to a wide variety of harmful substances, of both endogenous and exogenous origin. These toxins can disrupt normal bodily functions and cause tissue damage. To neutralise these harmful substances effectively, the body uses an extensive network of detoxification enzymes.
Genetic variations play an important role in the effectiveness of these enzymes. When specific genetic variations are present, the functioning of the detoxification enzymes can be reduced, leading to a disrupted detoxification process. Inefficient detoxification can contribute to a wide range of physical symptoms and health problems.
Routes and enzymes involved
Phase 0: uptake via transport proteins (SLCs)
Phase 1: modification of binding sites by oxidation, reduction, hydrolysis or hydroxylation, including by CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, NQO1, PON1 and the alcohol dehydrogenases
Phase 2: conjugation via glutathione (GSTs), glucuronidation (UGTs), sulfation (SULTs), acetylation (NATs) and methylation (MTs)
Phase 3: export via transport proteins (ABCs)
Genetic factors
Genetic variations and mutations can be of crucial importance for the functionality of proteins, such as enzymes or transport proteins. Such genetic abnormalities can lead to reduced activity, complete inactivity or, conversely, accelerated action of an enzyme.
Not every individual abnormal enzyme or transport protein has the same impact – this depends largely on the type of toxin that has to be metabolised. By looking at combinations of enzymes and genetic variants, better insight can be gained into the effectiveness of the detoxification process as a whole.
Clinical relevance and other factors
For effective detoxification it is essential that both phases of detoxification run efficiently. When phase 2 is delayed, the oxidising intermediate products formed during phase 1 cannot be metabolised further quickly enough. This can lead to the accumulation of harmful intermediate products, which can cause tissue damage.
Cofactors are required for these enzymes to work optimally, including vitamin B2, B3, B6, B12, C, folic acid, iron, zinc, copper, magnesium, manganese, selenium and molybdenum. The gut flora and the acidity of the urine also influence the detoxification process.
The process illustrated
In the dashboard you see this diagram with your client’s result in it: for each step whether an enzyme works normally, more slowly or more quickly, and which cofactors play a role.
Detoxification in four phases: from uptake (phase 0) to elimination via bile, kidneys and skin (phase 3).
Process 3 of 7
Oxidative stress
During the many chemical processes in the body, reactive substances are formed, such as oxygen radicals (ROS). These can damage cell membranes, enzymes, DNA and other structures, which is known as oxidative stress. The body protects itself against this through a cooperating combination of antioxidant enzymes, endogenous antioxidants and antioxidant substances from food.
Genetic variants influence the effectiveness of antioxidant enzymes and can disrupt the neutralisation of oxygen radicals. When oxidative stress is insufficiently neutralised, this can (in the long term) contribute to various health problems.
Catalase (CAT) and glutathione peroxidase (GPx): break down hydrogen peroxide into water and oxygen
Glutathione transferases (GSTs)
NOS3 (eNOS) and glucose-6-phosphate dehydrogenase (G6PD)
Genetic factors
Genetic variations and mutations can influence the functionality of enzymes. For many antioxidant enzymes, polymorphisms are known that can have a considerable impact on enzyme activity.
However, a single abnormality does not necessarily lead to problems straight away. That is why the combination of the antioxidant enzymes involved is made clear, which can help in understanding unexplained symptoms. In addition, targeted advice can be given to support weak links.
Clinical relevance and other factors
Many conditions and signs of ageing are linked to radical damage, which over time can leave irreparable traces. Cardiovascular disease, lung conditions, diabetic complications and cancer are some examples.
In addition to genetic predisposition, lifestyle and environmental factors also play a crucial role in protection against oxidative damage. A healthy diet with sufficient cofactors and antioxidants, healthy gut flora, a balanced stress level and sufficient exercise can fully or partly compensate for genetic weaknesses.
The process illustrated
In the dashboard you see this diagram with your client’s result in it: for each step whether an enzyme works normally, more slowly or more quickly, and which cofactors play a role.
Oxidative stress: the enzymes that neutralise ROS, such as SOD, CAT and GPX.
Process 4 of 7
Oestrogens
An optimal amount and balance of oestrogens, combined with efficient detoxification, is essential for health. When the hormone balance is disrupted, this can lead to oestrogen dominance: a situation in which strong-acting oestrogens are present in excess. This can be the result of increased production or delayed breakdown of oestrogens.
Genetic variants play a crucial role in the enzyme activity involved in both the production and the breakdown of oestrogens. Abnormalities in these processes can disrupt the hormone balance and contribute to various health problems.
Routes and enzymes involved
Synthesis: CYP17A1 and CYP19A1 (aromatase)
Hydroxylation: CYP1B1 (4-hydroxy form), CYP1A1, CYP1A2 and CYP3A4/5 (2- and 16α-hydroxy form)
Methylation via COMT, with SAM as cofactor
Quinones: recycling via NQO1 and elimination via glutathione transferases (GSTs)
Buffering via glucuronidation and sulfation: UGT1A1, SULT1A1 and SULT1E1
Genetic factors
Genetic variations and mutations can be of essential importance for the functionality of proteins, such as enzymes. Within oestrogen metabolism, too, polymorphisms are known that can considerably influence enzyme activity. Although not all variations have equally large consequences, a combined analysis of the enzymes involved offers valuable insight into the overall efficiency of this metabolic process.
In addition to genetic predisposition, environmental factors also play a crucial role. Exogenous substances, such as xenoestrogens (e.g. pesticides, parabens, phthalates, PCBs, additives, cosmetics, perfume and cleaning products), as well as phytoestrogens, can influence the hormone balance as endocrine disruptors.
Clinical relevance and other factors
Oestrogen dominance indicates an imbalance between oestrogens and progesterone, with an excess of strong-acting oestrogens. Possible symptoms of oestrogen dominance (hyperoestrogenism):
irregular menstruation
worsened PMS symptoms
swollen and tender breasts
fibrosis and cysts in the breasts
bloated feeling (bloating)
reduced libido
abdominal weight gain
mood swings
headache
insomnia
tiredness
brain fog
anxiety and panic attacks
lethargy and depression
The process illustrated
In the dashboard you see this diagram with your client’s result in it: for each step whether an enzyme works normally, more slowly or more quickly, and which cofactors play a role.
Oestrogens: from production to breakdown and elimination.
Process 5 of 7
Neurotransmitters
Neurotransmitters are signalling substances that enable communication between nerve cells (neurons) in the nervous system. Important neurotransmitters are dopamine, noradrenaline, adrenaline, histamine, serotonin, oxytocin, endorphin and GABA. Each neurotransmitter can bind to different receptors, which leads to varied physiological and psychological responses.
Genetic variations influence enzymes involved in the synthesis and breakdown of neurotransmitters. In addition, genetic variations can change the functionality of receptors. Reduced enzyme activity can lead to delayed production or breakdown of neurotransmitters, which disrupts their balance.
Routes and enzymes involved
Dopamine: production via TH and DDC, breakdown via COMT, MAOA and MAOB, and the receptors DRD1 to DRD4 inclusive
(Nor)adrenaline: breakdown via COMT, MAOA and ALDH2, and the β2 receptor (ADRB2)
Serotonin: the 5-HT1A and 5-HT2A receptors
Histamine: production via HDC, breakdown via DAO (AOC1), HNMT and possibly NAT2
Oxytocin (OXTR) and endorphin (OPRM1)
Genetic factors
Genetic variations and mutations can considerably influence the functionality of proteins, such as enzymes and receptors. Polymorphisms are also known in the production, breakdown and activation of neurotransmitters. Although not all functional abnormalities have large consequences, an analysis of the combined activity of enzymes and receptors offers valuable insights into the overall efficiency of this process.
Clinical relevance and other factors
When certain neurotransmitters are produced or broken down with a delay, for example because of less active enzymes, the balance of neurotransmitters can be disrupted. This can lead to a wide range of psychological or neurodegenerative symptoms, depending on the neurotransmitter involved.
In addition to genetic predisposition, other factors are also important. For example, (childhood) trauma, upbringing, and lifestyle and environmental factors, such as eating pattern, sufficient cofactors, stress, exercise and gut flora, can influence genetic programming (epigenetics).
The process illustrated
In the dashboard you see this diagram with your client’s result in it: for each step whether an enzyme works normally, more slowly or more quickly, and which cofactors play a role.
Dopamine, (nor)adrenaline and serotonin: production and breakdown.
Histamine: production and breakdown.
Process 6 of 7
Vitamins and minerals
Vitamins and minerals are indispensable nutrients that play a crucial role in numerous bodily functions. For optimal absorption, transport, activation, recycling and sometimes excretion, specific proteins are needed. Without these proteins, vitamins cannot be used effectively by the body.
Genetic variants influence the functioning of enzymes and transport proteins involved in these processes. This can give rise to individual differences in vitamin requirements, which makes a personalised approach to nutrition and supplementation essential.
Routes and enzymes involved
Absorption, transport, activation, excretion and recycling of vitamins
Vitamins A, D, C and E and the B vitamins, which support enzymatic conversions as cofactors
Water-soluble and fat-soluble vitamins
Genetic factors
Some vitamins only become active after they have been converted into their active form. This process is regulated by enzymes, the functioning of which can be influenced by genetic variations. Genetic differences can influence the absorption, transport, activation, excretion and recycling of vitamins, leading to individual differences in vitamin requirements.
Clinical relevance and other factors
This field, known as nutrigenetics, makes it possible to develop personalised nutritional advice based on a person’s genetic constitution. By applying this knowledge, nutrition can be better tailored to individual needs, which optimises the effectiveness of vitamin intake.
Diagram: not yet available in the image library, to be added.
Process 7 of 7
Inflammation
Inflammation is a natural protective mechanism of the body against pathogens, harmful substances and damaged cells or tissues. This process comprises a complex chain of biochemical reactions, in which immune cells, blood cells and cytokines (substances that promote inflammation) play a crucial role.
Genetic variants influence the functioning of inflammation enzymes and cytokines, which can lead to a disrupted balance in the inflammatory response. An increased tendency towards inflammation is linked to various health problems and conditions.
Routes and enzymes involved
Pro-inflammatory cytokines, such as IL-1A, IL-1B, IL-6 and TNFα
The anti-inflammatory cytokine IL-10
The relationship with oxidative stress (ROS)
Genetic factors
Genetic variations and mutations can have a substantial influence on the functionality of a protein, such as an enzyme or a receptor. The activity of both pro- and anti-inflammatory cytokines is also partly determined by genetic factors, which contributes to individual differences in susceptibility to inflammation.
Clinical relevance and other factors
Increased susceptibility to inflammation is linked to a wide range of symptoms and conditions, including tiredness, allergies, autoimmune diseases, cardiovascular disease, obesity, diabetes, Alzheimer’s and depression. Chronic, low-grade inflammation (Low Grade Inflammation) forms the basis of many Western diseases.
In addition to genetic predisposition, environmental and lifestyle factors also play a role in inflammation, such as stress, sex hormones, oxidative stress, nutrition, gut health and gut flora. Diet, and the gut flora that goes with it, is crucial in this.
The process illustrated
In the dashboard you see this diagram with your client’s result in it: for each step whether an enzyme works normally, more slowly or more quickly, and which cofactors play a role.
Pro- and anti-inflammatory signalling substances.
Curious what DNA analysis can mean in your practice?
DNA DASHBOARD