Warfarin and the enzymes VKORC1 and CYP2C9
Warfarin is processed within the body primarily by the enzymes VKORC1 and CYP2C9. The activity of these enzymes can vary considerably depending on your genetic predisposition, which means the efficacy of warfarin can also differ from person to person.
Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to the effectiveness of the treatment, for adjustment of the dose or for more frequent checks by the thrombosis clinic.
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