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Siponimod is a drug that suppresses the function of the immune system. It is a so-called selective sphingosine-1-phosphate receptor modulator.

Siponimod is prescribed to treat multiple sclerosis (MS), in particular for the treatment of adults with secondary progressive multiple sclerosis (both relapsing and non-relapsing).

Siponimod and the benefit of DNA analysis

The rate at which siponimod is processed within your body varies from one individual to another. This means that the efficacy and side effects of siponimod can be predicted to some extent on the basis of your genes. Preventive DNA analysis can therefore be an important tool in optimising your medication.

Siponimod and the enzyme CYP2C9

Siponimod is processed to a large extent by the enzyme CYP2D6 and to a lesser extent by the enzyme CYP3A4. The activity of the CYP2C9 enzyme can vary considerably depending on your genetic predisposition, which means the efficacy of siponimod can also differ from person to person.

Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with siponimod.

Read more about CYP2C9 enzyme »

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