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Sertraline is an antidepressant forming part of the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). It inhibits the reuptake of the neurotransmitter serotonin in the brain. Sertraline improves the mood and reduces anxiety, and is used to treat depression, anxiety disorders, neuralgia, premenstrual syndrome, certain types of itch, hiccups and premature ejaculation.

Sertraline and the benefit of DNA analysis

The rate at which sertraline is processed within your body varies from one individual to another. This means that the efficacy and side effects of sertraline can be predicted to some extent on the basis of your genes. Preventive DNA analysis can therefore be an important tool in optimising your medication.

Sertraline and the enzyme CYP2C19

Sertraline is processed within the body primarily by the enzyme CYP2C19. The activity of this enzyme can vary considerably depending on your genetic predisposition, which means the efficacy of sertraline and the risk of side effects can also differ from person to person.

Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with sertraline.

Read more about CYP2C19 enzyme »

Also known as

Zoloft, Sertralina, Sertraline, Sertralinum, Lustral
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