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IS A DNA TEST RIGHT FOR ME?

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Oxcarbazepine

Oxcarbazepine is an anticonvulsant forming part of the class of drugs known as sodium channel blockers. It calms overstimulated nerves in the brain by influencing the transmission of information via the nerves. Oxcarbazepine is prescribed to treat epilepsy, manic depression, neuralgia, diabetes insipidus and alcohol withdrawal. The risk of side effects resulting from a treatment with oxcarbazepine varies from one individual to another.

Oxcarbazepine and the benefit of DNA analysis

The risk of side effects resulting from a treatment with oxcarbazepine varies from one individual to another. This means that the efficacy and side effects of oxcarbazepine can be predicted to some extent on the basis of your genes. Preventive DNA analysis can therefore be an important tool in optimising your medication.

Oxcarbazepine and the HLA-A*3101 and HLA-B*1502 genes

As a result of genetic variations, your body may not produce certain proteins or may produce them with an abnormal composition, potentially changing the way in which drugs are processed.

It is known, for example, that mutations in the HLA-B*1502 gene can increase the risk of (serious) side effects. The role of the HLA-A*3101 gene is probably more limited.

Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with oxcarbazepine.

Read more about HLA-A*3101 / HLA-B*1502 »
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