Nortriptyline and the enzyme CYP2D6
Nortriptyline is processed to a large extent by the enzyme CYP2D6.
The activity of this enzyme can vary considerably depending on your genetic predisposition, which means the efficacy of nortriptyline can also differ from person to person. Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with nortriptyline.
*The enzyme CYP2C19 also plays a (limited) role in the processing of nortriptyline. However, no specific guidelines have been formulated on the basis of this enzyme.
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