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Flucytosine is an antimycotic, or antifungal, drug. It kills infection-causing fungi or inhibits their growth. The drug is also active against fungi-like yeasts, such as Candida. Flucytosine is used for serious yeast and fungal infections such as meningitis caused by Cryptococci or for serious Candida infections. It is usually used in combination with other antifungal medicines.

Flucytosine and the benefit of DNA analysis

The rate at which flucytosine is processed within your body varies from one individual to another. This means that the efficacy and side effects of flucytosine can be predicted to some extent on the basis of your genes. Preventive DNA analysis can therefore be an important tool in optimising your medication.

Flucytosine and the enzyme DPD

A small proportion of flucytosine is converted to fluorouracil within the body. Fluorouracil is processed primarily by the enzyme DPD. The activity of this enzyme can vary considerably depending on your genetic predisposition, which means the efficacy of flucytosine can also differ from person to person.

Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with flucytosine.

Read more about DPD enzyme »

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