Atorvastatin is a cholesterol synthesis inhibitor forming part of the statin family. Atorvastatin lowers cholesterol and reduces hardening of the arteries. It is used to treat a high cholesterol level in the blood and cardiovascular diseases. The drug is also prescribed to treat conditions associated with an increased risk of cardiovascular diseases, such as diabetes or high blood pressure.
Atorvastatin and the benefit of DNA analysis
The rate at which atorvastatin is processed within your body varies from one individual to another. This means that the efficacy and side effects of atorvastatin can be predicted to some extent on the basis of your genes.
Preventive DNA analysis can therefore be an important tool in optimising your medication.
Atorvastatin and the transport protein SLCO1B1
Atorvastatin is transported within the body (from the blood to the liver) primarily by the transport protein SLCO1B1. The activity of this transport protein can vary considerably depending on your genetic predisposition, which means the extent and nature of potential side effects can differ from person to person.
Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with atorvastatin.
Read more about SLCO1B1 transport protein »
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