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The enzyme BChE

The enzyme BChE (butyrylcholinesterase, also known as pseudocholinesterase) plays a role in the metabolisation of various drugs, such as certain muscle relaxants and local anaesthetics. BChE is an enzyme that prevents toxic substances from reaching the nervous system. These include pesticides and neurotoxins, for example, but also natural toxins such as solanine, which is naturally present in the green parts of potatoes. Certain drugs are also metabolised by the enzyme BChE and thereby inactivated.

Mivacurium and the enzyme BChE

Mivacurium is processed within the body primarily by the enzyme BChE (butyrylcholinesterase). The activity of this enzyme can vary considerably depending on your genetic predisposition, which means the efficacy of mivacurium can also differ from person to person.

Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with mivacurium.

Read more about Mivacurium »

Succinylcholine and the enzyme BChE

Succinylcholine is processed within the body primarily by the enzyme BChE (butyrylcholinesterase). The activity of this enzyme can vary considerably depending on your genetic predisposition, which means the efficacy of succinylcholine can also differ from person to person.

Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with succinylcholine.

Read more about Succinylcholine »

Genetic predisposition
The activity of the enzyme BChE varies from one individual to another. This variation is partly explained by genetic variations in the BChE gene. An underactive BChE enzyme can lead to muscle relaxants such as succinylcholine and mivacurium, and local anaesthetics like cocaine and procaine, building up in the body and causing side effects. Such reduced activity, also known as pseudocholinesterase deficiency, occurs in around 1 in 2,500 people. In people with pseudocholinesterase deficiency the (respiratory) muscles may remain relaxed for hours, meaning that mechanical ventilation may be necessary for a long period.
When a genotype is determined these variations in the BChE gene are indicated by two so-called alleles. Each allele has a name consisting of an asterisk (*) and a letter. An example of a possible BChE genotype is BChE*U/*U (U stands for Usual).
At iGene we determine the following variants (alleles) of the BChE gene: BChE*A, BChE*F1, BChE*F2, BChE*K, BChE*J, BChE*S and other (classified as BChE*U).